2017

Regeneration of cortical tissue from brain injury by implantation of defined molecular gradient of semaphorin 3A.

Authors Zhen Xua, Wang W, Yutian Ren, Wenchong Zhang, Peilin Fang, Linfeng Huang, XinWang, Peng Shi. Biomaterials 2018 Abstract Despite great efforts in the exploration of therapeutic strategies for treating brain injuries, it is still challenging to regenerate neural tissues and to restore the lost function within an injured brain. In this report, we employed a tissue engineering approach to regenerate cortical tissue from brain injury by implantation of defined semaphorin 3A (Sema3A) gradient packaged in a hydrogel based device.

A MicroRNA Signature Associated With Metastasis of T1 Colorectal Cancers to Lymph Nodes.

in Gastroenterology

May 3046, 30118

Authors Ozawa T†, Kandimalla R†, Gao F†, Nozawa H, Hata K, Nagata H, Okada S, Izumi D, Baba H, Fleshman J, Wang X, Watanabe T, Goel A. Gastroenterology 2017 Abstract Most T1 colorectal cancers treated by radical surgery can now be cured by endoscopic submucosal dissection. Although 70%-80% of T1 colorectal cancers are classified as high risk, <16% of these patients actually have lymph node metastases. Biomarkers are needed to identify patients with T1 cancers with the highest risk of metastasis, to prevent unnecessary radical surgery.

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.

in Cell Death and Differentiation

May 931, 9108

Authors Linnekamp JF†, van Hooff SR†, Prasetyanti PR, Kandimalla R, Buikhuisen JY, Fessler E, Ramesh P, Lee KAST, van Bochove GGW, de Jong JH, Cameron K, van Leersum R, Rodermond HM, Franitza M, Nürnberg P, Mangiapane LR, Wang X, Clevers H, Vermeulen L, Stassi G and Medema JP. Cell Death and Differentiation 2018, doi:10.1038/s41418-017-0011-5 Abstract Colorectal cancer (CRC) is a highly heterogeneous disease both from a molecular and clinical perspective.

Genome-wide Discovery of a Novel Gene-expression Signature for the Identification of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma.

in Annals of Surgery

May 1031, 10098

Authors Fuminori Sonohara; Feng Gao; Naoki Iwata; Mitsuro Kanda; Masahiko Koike; Naoki Takahashi; Yasuhide Yamada; Yasuhiro Kodera; Wang X*; Ajay Goel Annals of Surgery 2017, doi:10.1097/SLA.0000000000002622 Objective This study aimed to develop a gene-expression signature for identification of lymph node (LN) metastasis in esophageal squamous cell carcinoma (ESCC) patients. Summary of Background Data LN metastasis is recognized as the most important independent risk factor for therapeutic decision-making of ESCC patients.

Regeneration of cortical tissue from brain injury by implantation of defined molecular gradient of semaphorin 3A.

A MicroRNA Signature Associated With Metastasis of T1 Colorectal Cancers to Lymph Nodes.

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.

Genome-wide Discovery of a Novel Gene-expression Signature for the Identification of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma.

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